His family confirmed the news in a social media statement, saying he passed away in his sleep of natural causes. They remembered him as passionate, sensitive, and deeply creative, noting that his artistic pursuits—especially painting in recent years—were a true reflection of who he was.
Brendon portrayed Xander Harris, the loyal best friend of Buffy, played by Sarah Michelle Gellar, throughout the show’s seven-season run from 1997 to 2003. Following the news of his death, Gellar paid tribute by quoting a well-known monologue from his character, adding, “I saw you Nicky… I know you are at peace, in that big rocking chair in the sky.” Co-star Alyson Hannigan also honored him, thanking him for years of laughter and friendship in a heartfelt Instagram post.

The Los Angeles-born actor earned three Saturn Award nominations for his work on Buffy—two for Best TV Actor and one for Best Supporting Actor. His twin brother, Kelly Donovan Schultz, even served as his body double in two episodes of the series. After Buffy, Brendon continued acting with appearances in shows such as Criminal Minds, Private Practice, and Kitchen Confidential. His film credits included Psycho Beach Party, Big Gay Love, and Redwood.

Brendon was also open about his personal and health challenges. He survived a heart attack and underwent two spinal surgeries related to cauda equina syndrome, a rare condition affecting mobility and bodily function. He lived with a stutter and later became an advocate as a spokesperson for the Stuttering Foundation of America. The actor also spoke publicly about struggles with addiction, alcoholism, and mental health. According to his family, he had been receiving treatment and was optimistic about the future at the time of his passing.